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Dofequidar fumarate

CAS No. 153653-30-6

Dofequidar fumarate ( MS-209 )

Catalog No. M12171 CAS No. 153653-30-6

A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 41 Get Quote
5MG 69 Get Quote
10MG 114 Get Quote
25MG 232 Get Quote
50MG 447 Get Quote
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Biological Information

  • Product Name
    Dofequidar fumarate
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
  • Description
    A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR; completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM; greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.Breast cancer Phase 2 Discontinued
  • Synonyms
    MS-209
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P-glycoprotein
  • Recptor
    P-glycoprotein
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    153653-30-6
  • Formula Weight
    597.66
  • Molecular Formula
    C34H35N3O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 56 mg/mL
  • SMILES
    C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5.C(=CC(=O)O)C(=O)O
  • Chemical Name
    Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-, (2E)-2-butenedioate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.
2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.
3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.
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