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Dofequidar fumarate
CAS No. 153653-30-6
Dofequidar fumarate( MS-209 )
Catalog No. M12171 CAS No. 153653-30-6
A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | Get Quote |
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| 5MG | 69 | Get Quote |
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| 10MG | 114 | Get Quote |
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| 25MG | 232 | Get Quote |
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| 50MG | 447 | Get Quote |
|
| 100MG | 651 | Get Quote |
|
| 500MG | 1368 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDofequidar fumarate
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NoteResearch use only, not for human use.
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Brief DescriptionA novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
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DescriptionA novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR; completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM; greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.Breast cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMS-209
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PathwayMembrane Transporter/Ion Channel
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TargetP-glycoprotein
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RecptorP-glycoprotein
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number153653-30-6
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Formula Weight597.6576
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Molecular FormulaC34H35N3O7
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 56 mg/mL
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SMILESC1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5.C(=CC(=O)O)C(=O)O
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Chemical NameEthanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-, (2E)-2-butenedioate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.
2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.
3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.
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